Mitochondria

Summary of researh using electron tomography to study the invaginations in the mitochondrial inner membran.

Link: Mitochondria

The Kinetochore

Summary of research using Electron tomography to assess kinetochore modulation of microtubule dynamics.

Link: The Kinetochore

The Ribosome

Summary of research on interaction between the ribosome and its ligands during all steps of protein synthesis in a well-characterized E. coli translation system, using cryo-EM.

Link: The Ribosome

The Ryanodine Receptor

Summary of research on the functional states of the ryanodine receptor (RyR) and 3D structure of the triad junction.

Link: The Ryanodine Receptor

A Microscopical Study of Exotic Animal Hairs

From: McCrone Associates, Inc.
Link: A Microscopical Study of Exotic Animal Hairs

Analysis of Microscopic Material and the Stitching of the Dead Sea Scrolls, a Preliminary Study

Link: Analysis of Microscopic Material and the Stitching of the Dead Sea Scrolls, a Preliminary Study

Atlas of Igneous and Metamorphic Rocks, Minerals and Textures

Link: Atlas of Igneous and Metamorphic Rocks, Minerals and Textures

Micrographia

Micrographia is for those who use microscopes in their investigations of the world around them. It is for students and teachers of (especially) fresh water biology in their search for creature identification and illustrative material,and for anyone at all who feels like a browse through a minutely detailed world of small animals, small plants, and small things.

Link: Micrographia

Questioned Document Examination Page

The award winning site has information on the use of a comparison microscope for examining documents in civil and criminal legal cases, domestic disputes, and other controversies. Famous document cases are presented as examples.

Link: Questioned Document Examination Page

Resources for Paint Pigment Microscopists

From: McCrone Associates, Inc.
Link: Resources for Paint Pigment Microscopists

The Euglenoid Project

A research and teaching resource for students, teachers and researchers interested in the group of protists commonly known as, the euglenoids.

Link: The Euglenoid Project

Through the Microscope: Blood Cells

An internet gallery of health science images from light and electron microscopes.

Link: Through the Microscope: Blood Cells

Virtual Atlas of Opaque and Ore Minerals in Their Associations

Robert A. Ixer and Paul R. Duller, Department of Geological Sciences, Birmingham University and Kerr McGee Oil (UK) plc. Online atlas with 400 photomicrographs of ore minerals in reflected light. Well organized with cross referencing of samples by association, location, mineralogy, ore deposit type, minerals, texture, and properties. A great reference and teaching tool.

Link: Virtual Atlas of Opaque and Ore Minerals in Their Associations

Fishscope: Time-Lapse Recordings and Confocal Images Dealing With the Developmental Biology of Fish

Fishscope is a series of time lapse recordings of the development of zebra fish from early cleavage through the formation of organ rudiments.

Link: Fishscope: Time-Lapse Recordings and Confocal Images Dealing With the Developmental Biology of Fish

Building a Blueprint of the Cell's Protein Factory

HHMI Bulletin, January 2001

Link: Building a Blueprint of the Cell's Protein Factory

Electron microscopy of signalling proteins

Link: Electron microscopy of signalling proteins

Optical Aspirations

Article on the use of cryo electron microscopy to visualize tiny three-dimensional protein structures inside cells. Nikolaus Grigorieff's lab at HHMI.

Link: Optical Aspirations

Examination of Gunshot Residue

Firearms Tutorial, The Internet Pathology Laboratory for Medical Education

Link: Examination of Gunshot Residue

Fascinating Images Reveal Climbing Abilities of Geckos and Spiders

Using the ORION helium ion microscope from Carl Zeiss researchers from Lewis and Clark have revealed the finest structures on the feet of geckos and spiders. Based on these images the masterly climbing skills of these creatures is attributable to adhesive forces or, in other words, intermolecular attractions. The spatula-shaped tips of the tiny hairs, or "setae", that cover the undersides of the feet allow the creatures to make a vast number of contacts with the climbed surface. The simple adhesive force between all touching objects enables the gecko or spider to carry many times its own weight when climbing upside down. <br /><br />In helium ion microscopy static charge is neutralized and samples do not require coating as in electron microscopy that covers up the fine structures such as gecko and spider hairs. The specimen is imaged in its natural state resulting in a razor-sharp image that offer not only high scientific content, but also an outstanding degree of abstract

From: Carl Zeiss NTS - Nano Technology Systems
Link: Fascinating Images Reveal Climbing Abilities of Geckos and Spiders

FIM Group Research Projects and Image Gallery

Link: FIM Group Research Projects and Image Gallery

Graphene Nano-Ribbon Patterning

Helium ion microscopy (HIM) offers the ability to carry out both high precision ion machining and sub-nanometer resolution imaging with high surface sensitivity in order to inspect patterns created in graphene. Nano-ribbons can be machined narrow enough to get deep into the quantum confinement regime and also maintain very long aspect ratios.

From: Carl Zeiss NTS, LLC
Link: Graphene Nano-Ribbon Patterning

Helium Ion Beam Lithography in the ORION

This application note highlights the use of helium ion microscope (HIM) for direct write lithography in resists to create high feature density structures with critical dimensions below ten nanometers. The helium ion microscope provides a probe combining the small size available in electron beam systems with the favorable proximity effects of an ion.

From: Carl Zeiss NTS, LLC
Link: Helium Ion Beam Lithography in the ORION

Imaging with Long Depth of Field

The depth of field in the helium ion microscope can be five to ten times longer than in a typical SEM. Because the ion source is extremely small the ion optical column a helium ion microscope is run at a smaller demagnification than a typical SEM. Since depth of field is being inversely proportional to the convergence angle, the helium ion microscope images at a superior depth of field offers allowing foreground and background objects to be in good focus simultaneously.

From: Carl Zeiss NTS, LLC
Link: Imaging with Long Depth of Field

Nano-Pore Milling with the Helium Ion Microscope

The helium ion microscope produces a sub-nanometer size probe with a low mass ion. The beam has a tight spatial profile and a small convergence angle, both of which reduce aberrations. The sputtering rate is lower than for a gallium beam and sample interactions don’t spread the beam as quickly. Therefore sputtering events are much more likely to occur close to the beam axis. An example is shown based on the application of creating nmscale vias in a 100 nm thick gold layer.

From: Carl Zeiss NTS, LLC
Link: Nano-Pore Milling with the Helium Ion Microscope

Cell division drama unfolds under the microscope

Link: Cell division drama unfolds under the microscope

The mechanism by which chromosomal DNA molecules are held together: entrapment within cohesin rings?

Link: The mechanism by which chromosomal DNA molecules are held together: entrapment within cohesin rings?

In Situ High-Resolution Transmission Electron Microscopy in the Study of Nanomaterials and Particles

This article introduces the use of in situ high-resolution transmission electron

Link: In Situ High-Resolution Transmission Electron Microscopy in the Study of Nanomaterials and Particles

Movie of Individual Carbon Atoms in Action

Researchers used the world’s most powerful transmission electron microscope to make the first ever live action movie of the dynamics of carbon atoms. What they saw looks promising for spintronic-based computing.

Link: Movie of Individual Carbon Atoms in Action

Publications Search for the National Center for Electron Microscopy

Search for publications by keyword, author, or year. NCEM is one of the world's most advanced centers for electron microscopy. In addition to facility information, the site includes images, new research, and publications

Link: Publications Search for the National Center for Electron Microscopy

SuperSTEM

The SuperSTEM microscopes incorporate computer controlled aberration correction of the objective lens using quadrupole and octupole lenses. This allows the formation of a sub-Angstrom probe for simultaneous ultra-high resolution high angle annular dark field (HAADF) imaging and atomic-column electron energy loss spectroscopy (EELS) analysis of thin specimens.

Link: SuperSTEM

Image Analysis Reports from clemex

Link: Image Analysis Reports from clemex

Micro X-ray Fluorescence Map of Garnet Schist

Application of Micro XRF in a SEM to show the distribution of trace elements in a a garnet schist.

From: IXRF Systems, Inc.
Link: Micro X-ray Fluorescence Map of Garnet Schist

Contaminant Identification in Pharmaceutical Products

Article from The Microscope, Vol 51:1, 3-10 (2003)

From: McCrone Associates, Inc.
Link: Contaminant Identification in Pharmaceutical Products

Fluid-Rock Interactions and Biomineralization: Applications of Raman Spectroscopy and Mineralogy to Materials Science

Link: Fluid-Rock Interactions and Biomineralization: Applications of Raman Spectroscopy and Mineralogy to Materials Science

Electron Microscopy of Foods and Microorganisms

facinating site on the scanning electron microscopy of foods and food born bacteria. Images and articles from several microscopist are included.

Link: Electron Microscopy of Foods and Microorganisms

LT-SEM of Snow Crystals

Low Temperature Scanning Electron Microscope image

Link: LT-SEM of Snow Crystals

AFM Applications

From: Agilent Technologies - AFM
Link: AFM Applications

Moving molecules at room temperature

The demonstration that individual molecules can be moved and precisely positioned on a surface by means of a scanning tunneling microscope (STM), without lowering the temperature to near absolute zero, represents a key step on the road to creating new atomic and molecular structures .

Link: Moving molecules at room temperature

Scanning Probe Evolution in Biology

Link: Scanning Probe Evolution in Biology

SPM of Biological Systems in Food and Agriculture

Link: SPM of Biological Systems in Food and Agriculture

Disease Carriers: Explore the Microscopic World of Health Science

Learn about the science underlying public health issues by perusing -- and using -- digitized images on view.

Link: Disease Carriers: Explore the Microscopic World of Health Science

Virus Ultrastructure

This well done site includes principles of virus structure, Electron Microscopy:How images are created by negative staining, electron microscopy images, and lecture notes.

Link: Virus Ultrastructure

A Light for Science

Excellent brochures with details on applications.

Link: A Light for Science

Advanced Photon Source Science

Link: Advanced Photon Source Science

Biological imaging by soft x-ray diffraction microscopy

D. Shapiro, P. Thibault, T. Beetz, V. Elser, M. Howells, C. Jacobsen, J. Kirz, E. Lima, H. Miao, A. M. Neiman, and D. Sayre, Proceedings of the National Academy of Science 102 (43), 15343-15346 (2005).

Link: Biological imaging by soft x-ray diffraction microscopy

ESRF Scientific results in a nut-shell

Examples from all fields of science and industry.

Link: ESRF Scientific results in a nut-shell

Viewing Viral Structures

With the help of x-ray crystallography, a technique that enables scientists to deduce the positions of individual atoms in a structure, Luger and her collaborator Kenneth Kaye of Harvard Medical School have just discovered the devious way in which the Kaposi virus spreads

Link: Viewing Viral Structures

ESRF Scientific results in a nut-shell

Examples from all fields of science and industry.

Link: ESRF Scientific results in a nut-shell

Biological imaging by soft x-ray diffraction microscopy

D. Shapiro, P. Thibault, T. Beetz, V. Elser, M. Howells, C. Jacobsen, J. Kirz, E. Lima, H. Miao, A. M. Neiman, and D. Sayre, Proceedings of the National Academy of Science 102 (43), 15343-15346 (2005).

Link: Biological imaging by soft x-ray diffraction microscopy

A Light for Science

Excellent brochures with details on applications.

Link: A Light for Science

SPM of Biological Systems in Food and Agriculture

Link: SPM of Biological Systems in Food and Agriculture

Scanning Probe Evolution in Biology

Link: Scanning Probe Evolution in Biology

Fly Light Project

Link: Fly Light Project

The Fly EM Project

Using electron microscopy the Fly EM project at Janelia Farm is developing technology to create a map of every neuron and synapse in the Drosophila nervous system. By establishing a map or fly ‘connectome’ that shows how all neurons in the fly brain are connected to each other, this will lead to a better understanding of brain function. Over 8,000 serial sections have been used to collect hundreds of thousands images. The project includes development of a semi-automated pipeline for serial section TEM reconstruction and exploring Scanning Electron Microscopy with Focused Ion Beam Milling (SEM-FIB) and Scanning Transmission Electron Microscopy (STEM) for improved data acquisition.

Link: The Fly EM Project

The mechanism by which chromosomal DNA molecules are held together: entrapment within cohesin rings?

Link: The mechanism by which chromosomal DNA molecules are held together: entrapment within cohesin rings?

Optical Aspirations

Article on the use of cryo electron microscopy to visualize tiny three-dimensional protein structures inside cells. Nikolaus Grigorieff's lab at HHMI.

Link: Optical Aspirations

Building a Blueprint of the Cell's Protein Factory

HHMI Bulletin, January 2001

Link: Building a Blueprint of the Cell's Protein Factory

Analysis of Microscopic Material and the Stitching of the Dead Sea Scrolls, a Preliminary Study

Link: Analysis of Microscopic Material and the Stitching of the Dead Sea Scrolls, a Preliminary Study

Examination of Gunshot Residue

Firearms Tutorial, The Internet Pathology Laboratory for Medical Education

Link: Examination of Gunshot Residue

Questioned Document Examination Page

The award winning site has information on the use of a comparison microscope for examining documents in civil and criminal legal cases, domestic disputes, and other controversies. Famous document cases are presented as examples.

Link: Questioned Document Examination Page

Resources for Paint Pigment Microscopists

From: McCrone Associates, Inc.
Link: Resources for Paint Pigment Microscopists

A Microscopical Study of Exotic Animal Hairs

From: McCrone Associates, Inc.
Link: A Microscopical Study of Exotic Animal Hairs

Electron Microscopy of Foods and Microorganisms

facinating site on the scanning electron microscopy of foods and food born bacteria. Images and articles from several microscopist are included.

Link: Electron Microscopy of Foods and Microorganisms

Micro X-ray Fluorescence Map of Garnet Schist

Application of Micro XRF in a SEM to show the distribution of trace elements in a a garnet schist.

From: IXRF Systems, Inc.
Link: Micro X-ray Fluorescence Map of Garnet Schist

Fluid-Rock Interactions and Biomineralization: Applications of Raman Spectroscopy and Mineralogy to Materials Science

Link: Fluid-Rock Interactions and Biomineralization: Applications of Raman Spectroscopy and Mineralogy to Materials Science

Radiolaria

An introduction to the subject of micropaleontology based on microfossil images. It draws on over fifty years of experience teaching and researching into all aspects of micropaleontology.

Link: Radiolaria

Radiolaria.org

An online database containing information about radiolarians - fossil and recent, with images, descriptions, references, synonyms and links to other online resources.

Link: Radiolaria.org

Atlas of Igneous and Metamorphic Rocks, Minerals and Textures

Link: Atlas of Igneous and Metamorphic Rocks, Minerals and Textures

LT-SEM of Snow Crystals

Low Temperature Scanning Electron Microscope image

Link: LT-SEM of Snow Crystals

In Situ High-Resolution Transmission Electron Microscopy in the Study of Nanomaterials and Particles

This article introduces the use of in situ high-resolution transmission electron

Link: In Situ High-Resolution Transmission Electron Microscopy in the Study of Nanomaterials and Particles

ESRF Scientific results in a nut-shell

Examples from all fields of science and industry.

Link: ESRF Scientific results in a nut-shell

A Light for Science

Excellent brochures with details on applications.

Link: A Light for Science

Movie of Individual Carbon Atoms in Action

Researchers used the world’s most powerful transmission electron microscope to make the first ever live action movie of the dynamics of carbon atoms. What they saw looks promising for spintronic-based computing.

Link: Movie of Individual Carbon Atoms in Action

Publications Search for the National Center for Electron Microscopy

Search for publications by keyword, author, or year. NCEM is one of the world's most advanced centers for electron microscopy. In addition to facility information, the site includes images, new research, and publications

Link: Publications Search for the National Center for Electron Microscopy

Electron Microscopy of Foods and Microorganisms

facinating site on the scanning electron microscopy of foods and food born bacteria. Images and articles from several microscopist are included.

Link: Electron Microscopy of Foods and Microorganisms

The Euglenoid Project

A research and teaching resource for students, teachers and researchers interested in the group of protists commonly known as, the euglenoids.

Link: The Euglenoid Project

Radiolaria

An introduction to the subject of micropaleontology based on microfossil images. It draws on over fifty years of experience teaching and researching into all aspects of micropaleontology.

Link: Radiolaria

Radiolaria.org

An online database containing information about radiolarians - fossil and recent, with images, descriptions, references, synonyms and links to other online resources.

Link: Radiolaria.org

Moving molecules at room temperature

The demonstration that individual molecules can be moved and precisely positioned on a surface by means of a scanning tunneling microscope (STM), without lowering the temperature to near absolute zero, represents a key step on the road to creating new atomic and molecular structures .

Link: Moving molecules at room temperature

Contaminant Identification in Pharmaceutical Products

Article from The Microscope, Vol 51:1, 3-10 (2003)

From: McCrone Associates, Inc.
Link: Contaminant Identification in Pharmaceutical Products

Viewing Viral Structures

With the help of x-ray crystallography, a technique that enables scientists to deduce the positions of individual atoms in a structure, Luger and her collaborator Kenneth Kaye of Harvard Medical School have just discovered the devious way in which the Kaposi virus spreads

Link: Viewing Viral Structures

Virus Ultrastructure

This well done site includes principles of virus structure, Electron Microscopy:How images are created by negative staining, electron microscopy images, and lecture notes.

Link: Virus Ultrastructure